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Largest Cities in Missouri
Top 100 cities ranked by largest cities
Best Missouri Cities
Composite rankings combining multiple weighted metrics — 4 topics from climate and air quality data.
Largest Cities — Missouri
The largest cities in Missouri represent major centers of economic activity, cultural influence, and population growth. Kansas City leads with a population of 508,233, followed by St. Louis and Springfield. These cities serve as hubs for employment, education, and innovation, attracting residents from across the country and around the world.
Population size is a key indicator of a city's economic influence and infrastructure capacity. Larger cities typically offer more diverse job markets, extensive public transit systems, and a wider range of cultural amenities. MO dominates the top 10 with 10 cities on the list, reflecting the state's strong economic pull and quality of life.
While large populations bring economic advantages, they also present challenges including higher costs of living, traffic congestion, and housing affordability concerns. Many of these cities have experienced significant growth over the past decade, driven by job opportunities in technology, healthcare, and professional services.
Did You Know?
- 1. Kansas City's population is larger than that of many small nations.
- 2. MO has 10 cities in the top 10, more than any other state.
- 3. The 50th largest city still has a population of 17,282 — larger than most cities worldwide.
- 4. The top 5 cities combined have a population of 1,219,918.